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Currently, three clinically approved inhibitors: bortezomib (Velcade), carfilzomib (Kyprolis) and ixazomib (Ninlaro), directed towards all major proteasome forms are used for the treatment of hematological malignancies ( Collectively, these results underscore the importance of elucidating the distinct biological functions of proteasome subtypes

doi: 10.1007/s11284-013-1080-7 53 ElzingaC
Finding the bones in question, however, was another matter
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